HRT & Weight Loss Injections: What You Need to Know

Combining hormone replacement therapy (HRT) with weight loss injections like semaglutide (Wegovy, Ozempic) or tirzepatide (Mounjaro) is increasingly common. However, recent guidance from the British Menopause Society highlights potential interactions: these medications can slow digestion, possibly reducing the absorption of oral progesterone, a key component of HRT. This may compromise endometrial protection, especially for women with a uterus. Alternative progesterone delivery methods, such as the Mirena coil or combined HRT patches, are recommended. It's crucial to consult with a healthcare provider to adjust your treatment plan accordingly.