Progesterones and meningiomas
Recent studies have highlighted a potential link between certain progesterone-based medications and an increased risk of meningiomas, which are typically benign brain tumors. While these tumors are more common in women and often asymptomatic, some high-dose progestogens—such as medroxyprogesterone acetate (found in Depo-Provera), cyproterone acetate (found in Dianette), and nomegestrol acetate (found in Zoely)—have been associated with a higher risk of developing meningiomas. Notably, the risk appears to be dose-dependent, with prolonged use increasing the likelihood of tumor development. It's important to note that while these associations exist, the overall risk remains low, and more research is needed to fully understand the relationship between progesterone use and meningioma development. Women using these medications should consult with their healthcare providers to discuss potential risks and consider alternative options if necessary.
Diagnosing the perimenopause
Diagnosing perimenopause can be complex due to the absence of a definitive test. According to the British Menopause Society, perimenopause is characterized by changes in menstrual cycle patterns, such as infrequent periods and cycles becoming slightly longer, e.g., 6–7 weeks apart. Common symptoms include hot flushes, night sweats, cognitive changes, mood swings, sleep disturbances, and urogenital symptoms like vaginal dryness. In some cases, a trial of hormone replacement therapy (HRT) may be used to assess symptom improvement. It's essential to consult with a healthcare provider to evaluate symptoms and consider appropriate treatment options.
Cycle mapping - how best to monitor your menstrual cycle
Cycle mapping involves tracking key female hormones—LH, FSH, estradiol, and progesterone—throughout your menstrual cycle to assess ovulation and hormone patterns. Unlike traditional single-point blood tests, cycle mapping provides a comprehensive view, especially beneficial for those with irregular cycles, perimenopausal symptoms, or fertility concerns. Utilizing advanced tools like the Mira hormone monitor, which offers real-time, quantitative data, can enhance accuracy in tracking hormonal fluctuations. This approach aids in identifying ovulation timing, luteal phase length, and menopausal progression, facilitating informed healthcare decisions.
Berberine for PCOS
Berberine could help lower testosterone levels and the LH to FSH ratio compared to a placebo or no treatment.
Hormones and sleep during the menopause
Menopause brings about significant hormonal changes that can disrupt sleep patterns. Declining levels of estrogen and progesterone, along with reduced melatonin production, often lead to symptoms like night sweats, insomnia, and early morning awakenings. These disturbances can contribute to anxiety and depression, creating a challenging cycle. Hormone Replacement Therapy (HRT), particularly when combined with progesterone, has been shown to improve sleep quality by reducing night sweats and promoting deeper, more restorative sleep. Unlike sleeping tablets, HRT addresses the underlying hormonal causes of sleep disturbances, offering a more sustainable solution. For women in perimenopause, micronized progesterone can alleviate both sleep issues and heavy periods. Consulting with a healthcare provider can help determine the most appropriate treatment tailored to individual needs.
The role of the microbiome in phytoestrogens
The gut microbiome plays a crucial role in metabolising phytoestrogens—plant-derived compounds found in foods like soy, flaxseeds, and legumes. These compounds can mimic estrogen in the body, potentially alleviating menopausal symptoms and supporting hormonal balance. However, their effectiveness depends on the composition of an individual's gut bacteria. Certain gut microbes are better equipped to convert phytoestrogens into bioactive forms that the body can utilise. A diverse and healthy microbiome enhances this conversion, while an imbalanced microbiome may reduce efficacy. Factors such as diet, antibiotic use, and lifestyle choices can influence gut health and, consequently, the benefits derived from phytoestrogens. Maintaining a balanced microbiome through a fiber-rich diet, probiotics, and prebiotics may optimise the health benefits of phytoestrogens.
The Gut Microbiome and Cardiovascular Health
Diet plays a crucial role in cardiometabolic health, influencing both the composition of the microbiome as well as the development of related diseases. The gut microbiome, in particular, has been found to contribute to conditions such as hypertension, obesity, and diabetes through its impact on inflammation, insulin sensitivity, and blood lipid levels. A healthy gut microbiome is one that promotes long-term stability, resists infection, and helps the host maintain metabolic and immune balance.
Anastrazole for breast cancer prevention
Anastrazole has a license for the prevention in post-menopausal women with a moderate of high risk of developing breast cancer
Non-alcoholic liver disease
NAFLD is a common condition, particularly in women with PCOS. A lifestyle approach is important in preventing its progression to more serious disease and there is also some evidence for the use of complementary therapies like vitamin E.
Metformin & PCOS
Sirona Health is pleased to share the latest evidence-based recommendations for managing Polycystic Ovary Syndrome (PCOS) using Metformin.
Somatic therapy
Somatic therapy is a body-focused treatment that helps individuals process and release trauma stored in the body. Unlike traditional talk therapies, somatic therapy emphasises the connection between mind and body, recognizing that physical sensations can reflect emotional experiences. Through techniques such as body awareness, grounding, titration, sequencing, and pendulation, individuals can become more attuned to their bodily sensations, allowing for the safe release of tension and trauma-related stress. This approach can be particularly beneficial for those dealing with post-traumatic stress disorder (PTSD), chronic pain, and other stress-related conditions. By integrating bodily awareness into the healing process, somatic therapy offers a holistic path to recovery.
Ultra-processed foods
Ultra-processed foods consumption has been associated with a worse cardiometabolic risk profile and a higher risk of cardiovascular disease (angina and heart attacks), cerebrovascular disease, depression, and all-cause mortality. So, what are ultra-processed foods and how do we avoid them?
Painful periods since adolescence
Painful periods should be a call to action to improve the overall health status of the young woman suffering on a monthly basis
Empowerment in health & wellbeing
Empowerment can give you the ability to better self-manage your situation and have more influence over your determinants of health
5 Pillars of Wellbeing
At Sirona Health, we prioritize holistic care and are dedicated to helping you optimize the five pillars of well-being. By focusing on these pillars, we can not only improve your current health and well-being but also prevent future illness.
New treatment for chronic insomnia
Daridorexant will shortly be available in the UK for the treatment of chronic insomnia.
Non-steroidal painkillers and the ‘pill’ - new evidence of blood clot risk
Taking NSAIDs like ibuprofen with combined oral contraceptives (the pill) may increase the risk of blood clots (VTE). Studies suggest this combination can raise the risk significantly. If you’re on the pill, it’s safer to use paracetamol for pain relief and consult your healthcare provider before using NSAIDs—especially if you have additional risk factors like obesity or a history of clots.
Core values
Our core values are holisitic care, compassionate care, empowering women and using innovative healthcare.