HRT & Weight Loss Injections: What You Need to Know
Combining hormone replacement therapy (HRT) with weight loss injections like semaglutide (Wegovy, Ozempic) or tirzepatide (Mounjaro) is increasingly common. However, recent guidance from the British Menopause Society highlights potential interactions: these medications can slow digestion, possibly reducing the absorption of oral progesterone, a key component of HRT. This may compromise endometrial protection, especially for women with a uterus. Alternative progesterone delivery methods, such as the Mirena coil or combined HRT patches, are recommended. It's crucial to consult with a healthcare provider to adjust your treatment plan accordingly.
Bleeding on HRT - information for women who still have a womb
Experiencing vaginal bleeding while on hormone replacement therapy (HRT) is common, especially for women who still have a uterus. The type and timing of bleeding can vary depending on the HRT regimen—continuous or sequential. While light, short-duration bleeding is often considered normal, especially with sequential HRT, unscheduled or prolonged bleeding may indicate underlying issues such as endometrial hyperplasia or cancer. It's crucial to monitor bleeding patterns and consult with a healthcare provider if irregularities occur. Early detection and appropriate adjustments to HRT can help manage symptoms and reduce risks.
Long term safety of HRT
Hormone Replacement Therapy (HRT) remains a cornerstone in managing menopausal symptoms, offering relief from hot flushes, night sweats, and mood changes. While HRT is generally safe for women under 60, especially when initiated close to menopause onset, long-term use carries certain risks. These include a slightly increased risk of breast and ovarian cancers, as well as potential cardiovascular concerns if started many years post-menopause. However, for many women, the benefits—such as reduced risk of osteoporosis and improved quality of life—outweigh the risks. It's crucial to have a personalised discussion with a healthcare provider to weigh the pros and cons based on individual health profiles.
The role of the microbiome in phytoestrogens
The gut microbiome plays a crucial role in metabolising phytoestrogens—plant-derived compounds found in foods like soy, flaxseeds, and legumes. These compounds can mimic estrogen in the body, potentially alleviating menopausal symptoms and supporting hormonal balance. However, their effectiveness depends on the composition of an individual's gut bacteria. Certain gut microbes are better equipped to convert phytoestrogens into bioactive forms that the body can utilise. A diverse and healthy microbiome enhances this conversion, while an imbalanced microbiome may reduce efficacy. Factors such as diet, antibiotic use, and lifestyle choices can influence gut health and, consequently, the benefits derived from phytoestrogens. Maintaining a balanced microbiome through a fiber-rich diet, probiotics, and prebiotics may optimise the health benefits of phytoestrogens.